Tiplasinin or tiplaxtinin (PAI-039) is a drug which acts as an inhibitor of the serpin protein plasminogen activator inhibitor-1 (PAI-1), thereby increasing activity of the enzymes tissue plasminogen activator and urokinase, which are involved in the blood clotting cascade. Inhibition of PAI-1 can help to prevent damage to blood vessel walls that occurs as a consequence of chronic high blood pressure, as well as preventing the formation of blood clots that can lead to stroke and heart attack, and potentially also providing a novel treatment mechanism to slow the development of diabetes and obesity. Tiplasinin was unsuccessful in human clinical trials due to an unfavourable risk to benefit ratio and the need for tight dose control to avoid provoking bleeding disorders, however it is still widely used in scientific research and newer drugs sharing the same mechanism of action are likely to be developed for medical use in future.
"}{"fact":"Cats are subject to gum disease and to dental caries. They should have their teeth cleaned by the vet or the cat dentist once a year.","length":133}
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{"type":"standard","title":"Fontana bridge","displaytitle":"Fontana bridge","namespace":{"id":0,"text":""},"wikibase_item":"Q5465136","titles":{"canonical":"Fontana_bridge","normalized":"Fontana bridge","display":"Fontana bridge"},"pageid":17786648,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/5/5f/Fontanabridge.png","width":289,"height":563},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/5/5f/Fontanabridge.png","width":289,"height":563},"lang":"en","dir":"ltr","revision":"1275760092","tid":"ca2c6c17-eb25-11ef-b35e-04bb49faa1af","timestamp":"2025-02-14T22:48:21Z","description":"Version of bridge circuit","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Fontana_bridge","revisions":"https://en.wikipedia.org/wiki/Fontana_bridge?action=history","edit":"https://en.wikipedia.org/wiki/Fontana_bridge?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Fontana_bridge"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Fontana_bridge","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Fontana_bridge","edit":"https://en.m.wikipedia.org/wiki/Fontana_bridge?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Fontana_bridge"}},"extract":"A Fontana bridge is a type of bridge circuit that implements a wide frequency band voltage-to-current converter. The converter is characterized by a combination of positive and negative feedback loops, implicit in this bridge configuration. This feature allows compensation for parasitic impedance connected in parallel with the useful load , which in turn keeps an excitation current flowing through the useful load independent of the instantaneous value of . This feature is of great advantage for making electromechanical transducers.","extract_html":"
A Fontana bridge is a type of bridge circuit that implements a wide frequency band voltage-to-current converter. The converter is characterized by a combination of positive and negative feedback loops, implicit in this bridge configuration. This feature allows compensation for parasitic impedance ![](\"https://wikimedia.org/api/rest_v1/media/math/render/svg/1b646c9a79e850d2ed9206eb9616c5084a4eb7e4\")
![](\"https://wikimedia.org/api/rest_v1/media/math/render/svg/f35299f14001027f7c1494d579f8f8a3120e8666\")
![](\"https://wikimedia.org/api/rest_v1/media/math/render/svg/739e4a3281347351aa69ef7029b89791634f78bb\")